Restoring Memory Through Innovation

The Qiu lab aims to develop functional genomics and systems neuroscience tools to investigate the fundamental molecular mechanisms of memory formation and how these processes are perturbed in the early stages of neurodegenerative diseases. In particular, we focus on how traumatic brain injury or vascular insufficiency contribute to cognitive impairment, dementia, and Alzheimer's disease. To address these questions, we employ a wide range of in vivo neurobiology tools, including calcium imaging and optogenetics, alongside cutting-edge in vivo functional genomic approaches such as pooled CRISPR screens and deep mutational scanning.