2025

Chen, X. F., Kroke, B., Ni, J., Munoz, C., Appleman, M., Jacobs, B., Tran, T., Nguyen, K. V., Qiu, C., Stonestreet, B. S. & Marshall, J. 2025. Novel peptidomimetic compounds attenuate hypoxic-ischemic brain injury in neonatal rats. Experimental Neurology, 386, 115151.

2024

Qiu, C., Li, Z., Leigh, D. A., Duan, B., Stucky, J. E., Kim, N., Xie, G., Lu, K. P. & Zhou, X. Z. 2024. The role of the Pin1-cis P-tau axis in the development and treatment of vascular contribution to cognitive impairment and dementia and preeclampsia. Front Cell Dev Biol, 12, 1343962.

Qiu, C., Arora, P., Malik, I., Laperuta, A. J., Pavlovic, E. M., Ugochukwu, S., Naik, M. & Kaplan, C. D. 2024. Thiolutin has complex effects in vivo but is a direct inhibitor of RNA polymerase II in vitro. Nucleic Acids Res, 52, 2546-2564.

Lin, G., Barnes, C. O., Weiss, S., Dutagaci, B., Qiu, C., Feig, M., Song, J., Lyubimov, A., Cohen, A. E. & Kaplan, C. D. 2024. Structural basis of transcription: RNA polymerase II substrate binding and metal coordination using a free-electron laser. Proceedings of the National Academy of Sciences, 121, e2318527121.

Ke, S., Dang, F., Wang, L., Chen, J.-Y., Naik, M. T., Li, W., Thavamani, A., Kim, N., Naik, N. M., Sui, H., Tang, W., Qiu, C., Koikawa, K., Batalini, F., Stern Gatof, E., Isaza, D. A., Patel, J. M., Wang, X., Clohessy, J. G., Heng, Y. J., Lahav, G., Liu, Y., Gray, N. S., Zhou, X. Z., Wei, W., Wulf, G. M. & Lu, K. P. 2024. Reciprocal antagonism of PIN1-APC/CCDH1 governs mitotic protein stability and cell cycle entry. Nature Communications, 15, 3220.

Duan, B., Qiu, C., Lockless, S. W., Sze, S.-H. & Kaplan, C. D. 2024. Higher-order epistasis within Pol II trigger loop haplotypes. Genetics, 228.

2023

Jash, S., Banerjee, S., Cheng, S., Wang, B., Qiu, C., Kondo, A., Ernerudh, J., Zhou, X. Z., Lu, K. P. & Sharma, S. 2023. Cis P-tau is a central circulating and placental etiologic driver and therapeutic target of preeclampsia. Nature Communications, 14, 5414.

Guowu, L., Barnes, C. O., Weiss, S., Dutagaci, B., Qiu, C., Feig, M., Lyubimov, A., Song, J., Cohen, A. E. & Kaplan, C. D. 2023. Structural basis of transcription: RNA Polymerase II substrate binding and metal coordination at 3.0 Å using a free-electron laser. bioRxiv, 2023.09. 22.559052.

Dutagaci, B., Duan, B., Qiu, C., Kaplan, C. D. & Feig, M. 2023. Characterization of RNA polymerase II trigger loop mutations using molecular dynamics simulations and machine learning. PLoS Comput Biol, 19, e1010999.

Duan, B., Qiu, C., Sze, S. H. & Kaplan, C. 2023. Widespread epistasis shapes RNA Polymerase II active site function and evolution. bioRxiv, 2023.02. 27.530048.

Aron, L., Qiu, C., Ngian, Z. K., Liang, M., Drake, D., Choi, J., Fernandez, M. A., Roche, P., Bunting, E. L., Lacey, E. K., Hamplova, S. E., Yuan, M., Wolfe, M. S., Bennett, D. A., Lee, E. A. & Yankner, B. A. 2023. A neurodegeneration checkpoint mediated by REST protects against the onset of Alzheimer's disease. Nat Commun, 14, 7030.

2022

Dutagaci, B., Duan, B., Qiu, C., Kaplan, C. D. & Feig, M. 2022. Characterization of RNA Polymerase II Trigger Loop Mutations using Molecular Dynamics Simulations and Machine Learning. bioRxiv.

2021

Tomita, Y., Qiu, C., Bull, E., Allen, W., Kotoda, Y., Talukdar, S., Smith, L. E. H. & Fu, Z. 2021. Muller glial responses compensate for degenerating photoreceptors in retinitis pigmentosa. Exp Mol Med, 53, 1748-1758.

Qiu, C., Albayram, O., Kondo, A., Wang, B., Kim, N., Arai, K., Tsai, C. Y., Bassal, M. A., Herbert, M. K., Washida, K., Angeli, P., Kozono, S., Stucky, J. E., Baxley, S., Lin, Y. M., Sun, Y., Rotenberg, A., Caldarone, B. J., Bigio, E. H., Chen, X., Tenen, D. G., Zeidel, M., Lo, E. H., Zhou, X. Z. & Lu, K. P. 2021. Cis P-tau underlies vascular contribution to cognitive impairment and dementia, and can be effectively targeted by immunotherapy. Sci Transl Med, eaaz7615.

Koikawa, K., Kibe, S., Suizu, F., Sekino, N., Kim, N., Manz, T. D., Pinch, B. J., Akshinthala, D., Verma, A., Gaglia, G., Nezu, Y., Ke, S., Qiu, C., Ohuchida, K., Oda, Y., Lee, T. H., Wegiel, B., Clohessy, J. G., London, N., Santagata, S., Wulf, G. M., Hidalgo, M., Muthuswamy, S. K., Nakamura, M., Gray, N. S., Zhou, X. Z. & Lu, K. P. 2021. Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy. Cell, 184, 4753-4771 e27.

Kim, N., Wang, B., Koikawa, K., Nezu, Y., Qiu, C., Lee, T. H. & Zhou, X. Z. 2021. Inhibition of death-associated protein kinase 1 attenuates cis P-tau and neurodegeneration in traumatic brain injury. Prog Neurobiol, 203, 102072.

Garza, N. M., Griffin, A. T., Zulkifli, M., Qiu, C., Kaplan, C. D. & Gohil, V. M. 2021. A genome-wide copper-sensitized screen identifies novel regulators of mitochondrial cytochrome c oxidase activity. J Biol Chem, 296, 100485.

Fu, Z., Qiu, C., Cagnone, G., Tomita, Y., Huang, S., Cakir, B., Kotoda, Y., Allen, W., Bull, E., Akula, J. D., Joyal, J. S., Hellstrom, A., Talukdar, S. & Smith, L. E. H. 2021. Retinal glial remodeling by FGF21 preserves retinal function during photoreceptor degeneration. iScience, 24, 102376.

2020 and earlier

Qiu, C., Jin, H., Vvedenskaya, I., Llenas, J. A., Zhao, T., Malik, I., Visbisky, A. M., Schwartz, S. L., Cui, P., Cabart, P., Han, K. H., Lai, W. K. M., Metz, R. P., Johnson, C. D., Sze, S. H., Pugh, B. F., Nickels, B. E. & Kaplan, C. D. 2020. Universal promoter scanning by Pol II during transcription initiation in Saccharomyces cerevisiae. Genome Biol, 21, 132.

Qiu, C. & Kaplan, C. D. 2019. Functional assays for transcription mechanisms in high-throughput. Methods, 159-160, 115-123.

Albayram, O., Maciver, B., Mathai, J., Verstegen, A., Baxley, S., Qiu, C., Bell, C., Caldarone, B. J., Zhou, X. Z., Lu, K. P. & Zeidel, M. 2019. Traumatic Brain Injury-related voiding dysfunction in mice is caused by damage to rostral pathways, altering inputs to the reflex pathways. Scientific reports, 9, 1-12.

Lian, X., Lin, Y. M., Kozono, S., Herbert, M. K., Li, X., Yuan, X., Guo, J., Guo, Y., Tang, M., Lin, J., Huang, Y., Wang, B., Qiu, C., Tsai, C. Y., Xie, J., Gao, Z. J., Wu, Y., Liu, H., Zhou, X. Z., Lu, K. P. & Chen, Y. 2018. Pin1 inhibition exerts potent activity against acute myeloid leukemia through blocking multiple cancer-driving pathways. J Hematol Oncol, 11, 73.

Kozono, S., Lin, Y. M., Seo, H. S., Pinch, B., Lian, X., Qiu, C., Herbert, M. K., Chen, C. H., Tan, L., Gao, Z. J., Massefski, W., Doctor, Z. M., Jackson, B. P., Chen, Y., Dhe-Paganon, S., Lu, K. P. & Zhou, X. Z. 2018. Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells. Nat Commun, 9, 3069.

Malik, I., Qiu, C., Snavely, T. & Kaplan, C. D. 2017. Wide-ranging and unexpected consequences of altered Pol II catalytic activity in vivo. Nucleic Acids Res, 45, 4431-4451.

Qiu, C., Erinne, O. C., Dave, J. M., Cui, P., Jin, H., Muthukrishnan, N., Tang, L. K., Babu, S. G., Lam, K. C., Vandeventer, P. J., Strohner, R., Van den Brulle, J., Sze, S. H. & Kaplan, C. D. 2016. High-Resolution Phenotypic Landscape of the RNA Polymerase II Trigger Loop. PLoS Genet, 12, e1006321.

Wang, H., Qiao, Y., Chai, B., Qiu, C. & Chen, X. 2015. Identification and molecular characterization of the homogentisate pathway responsible for pyomelanin production, the major melanin constituents in Aeromonas media WS. PLoS One, 10, e0120923.

Braberg, H., Jin, H., Moehle, E. A., Chan, Y. A., Wang, S., Shales, M., Benschop, J. J., Morris, J. H., Qiu, C., Hu, F., Tang, L. K., Fraser, J. S., Holstege, F. C., Hieter, P., Guthrie, C., Kaplan, C. D. & Krogan, N. J. 2013. From structure to systems: high-resolution, quantitative genetic analysis of RNA polymerase II. Cell, 154, 775-88.